The Assault on Testosterone

The Assault on Testosterone



In the past several years there has been an exponential rise in the awareness of the importance of testosterone for men’s general and sexual health and well-being. Along with this increased awareness is an increased interest in ways to restore testosterone levels either naturally or through testosterone replacement therapy.



As well, although not as publicized, there has also been an increased awareness of the effects of low testosterone on women’s general and sexual health and well-being.[i][ii][iii]



And there are good reasons for all this increased concern since low serum testosterone can result in a myriad of symptoms including low libido, erectile and orgasmic dysfunction, increases in visceral fat, decreased muscle mass and bone mineral density, fatigue, depression, irritability, cognitive decline, and sleep disturbances, all of which can dramatically reduce well being and quality of life.[iv][v][vi][vii][viii][ix][x][xi][xii][xiii][xiv]



As we age, and in both men and women, testosterone levels decline.[xv][xvi] The reason for the decline include decreasing sensitivity to pituitary luteinizing hormone, decreases in the transporters of precursors such as cholesterol, and decreases in the steroidogenic enzymes of the mitochondria and smooth endoplasmic reticulum. Most of the changes that result in decreasing production of testosterone are thought to be due to oxidative damage that accumulates with time.



In middle aged men free testosterone levels drop by up to a few percentage points each year after the age of 30 to 35 and even more in elderly men. The usual 1% drop in total testosterone translates into more of a drop in the free testosterone due to an increase serum hormone binding globulin (SHBG), that basically inactivates some of the free testosterone. That drop alone is enough to negatively affect our body composition and physical performance as we age.



But there’s more than age involved as far as declining testosterone levels and that’s one of the reasons for the increase in concern among men. Epidemiological studies have shown that both fertility and testosterone levels have declined in men compared to what they were even 20 years ago.[xvii][xviii][xix][xx][xxi]



The reasons for this increased decline in testosterone levels may be due to a variety of factors including:[xxii][xxiii][xxiv][xxv][xxvi][xxvii][xxviii][xxix][xxx][xxxi][xxxii][xxxiii][xxxiv][xxxv][xxxvi][xxxvii][xxxviii][xxxix][xl][xli]




Endocrine disrupters may be one of the major reasons for the drop in testosterone in all men, regardless of age and in women as well. At present we’re surrounded by man made endocrine disruptors that can push testosterone levels into the basement, leaving men feeling less than a man both physically and functionally and women with lowered libido and increasing sexual dysfunction.



There are many pollutants and contaminants in our environment that act as endocrine disrupters, mainly from their toxicity and/or hormonal effects. These endocrine disruptors, which affect testosterone levels, semen quality, our health and feelings of well-being, are all around us including in our homes, in items we use every day and in our food, water and air.



It’s impossible to list them all but examples are pesticides, herbicides, synthetic fertilizers, parabens (in creams, lotions, sunscreens, shampoo, toothpaste), plastics that cover our food, and line cans used for both food and drink. They include dioxins, atrazine, phthalates, fire retardants, lead, mercury, non-stick cookware, organophosphates, glycol ethers, sprays and chemicals used to control pests, insects, and weeds, polycarbonate plastic, epoxy resins made from BPA, metals such as mercury, cadmium, and molybdenum, plant based phytoestrogens and fungi based mycoestrogens.[xlii]



The plant based phytoestrogens include the lignans and the natural phenolic compounds with the most common being the coumestans, prenylflavonoids and isoflavones (commonly found in soy and red clover).



Many of these endocrine disrupters affect us by increasing estrogen exposure and subsequently lowering testosterone, decreasing libido, and increasing sexual performance, including erectile dysfunction. Others affect the androgen receptor and decrease the binding of testosterone to the androgen receptor thus decreasing the beneficial effects of testosterone.




These endocrine disrupters work at many levels of the testosterone making machinery of our bodies, all the way from our brains, pituitary, adrenals and gonads, and many also affect binding to the androgen receptor. In men they can cumulative effects on the functioning of one or more levels of the hypothalamic-pituitary-testicular axis (HPTA) and the effects of testosterone.[xliii][xliv] The end result is a decrease in testosterone levels and activity, and increasing estrogenic effects since many of the chemicals are endocrine disrupters which mimic estrogen (xenoestrogens and phytoestrogens).



TestoBoost counters these and many other disrupting influences that keep your body from having your own natural optimal level of testosterone. As well, on top of countering negative epigenetic changes induced by our exposure to stress, drugs, pollutants, and estrogenic endocrine disruptors, it enhances positive epigenetic changes that allow our bodies to maximize our endogenous testosterone levels and effects, libido and sexual functioning at any age.



Just What Does TestoBoost Do?



TestoBoost (the new version V just out in September, 2015 - see Nutritional Panel below) does just what its name suggests, it boosts testosterone levels in both men and women. But it doesn’t increase testosterone levels by providing hormones or prohormones, it increases testosterone by two mechanisms. The first is by stimulating the natural endogenous production of testosterone via optimizing the hypothalamic-pituitary-gonadal axis, the natural testosterone making machinery in both men and women.



TestoBoost also increases the peripheral production of testosterone. However, this machinery is more important in women than men since ovarian production of testosterone is low and as such peripheral testosterone production can be important, while in healthy men testicular production of testosterone can be said to account for essentially all of their testosterone production.



But TestoBoost is not a hormone and doesn’t increase testosterone levels right away. Like almost all nutritional supplements, TestoBoost works by optimizing the internal environment so that your body ramps up testosterone more slowly so that you won’t see the full results until you’ve been diligently taking it for at least four weeks and in some cases even more.. As well, you will also see results on your health and well being over that time.



Who Uses TestoBoost?



TestoBoost is used mostly by men who want to enhance their testosterone levels. Many users have low testosterone levels and prefer boosting their own testosterone production rather than using the various forms of exogenous testosterone (injections, pellets, gels, sprays, etc.), all of which can carry significant adverse effects.



TestoBoost is used by scores of drug tested athletes for two main reasons. Unlike the use of testosterone and anabolic steroids, TestoBoost doesn’t shut down the Hypothalamic/Pituitary/Testicular axis (HPTA) and in fact enhances it. As such, there are no side effects involved with the use of TestoBoost and none when TestoBoost is discontinued.



More importantly for drug tested athletes TestoBoost, unlike the use of exogenous testosterone and anabolic steroids, also boosts the endogenous precursors all the way from cholesterol to testosterone, including epitestosterone – all in a natural way with no changes in the ratio of metabolites or the process, including not increasing any metabolite above the normal range. What it does is ramp up testosterone production up to optimum levels for the individual and not to pharmacological levels. All of what TestoBoost does and doesn’t do is the reason why it 100% won’t and can’t cause a positive drug test.



TestoBoost is also used by many middle aged and older men as hormonal replacement therapy since unlike the use of exogenous testosterone products, TestoBoost doesn’t shut down the Hypothalamic/Pituitary/Testicular axis (HPTA) and in fact enhances it. Also unlike exogenous testosterone TestoBoost also boosts the endogenous precursors in between cholesterol to testosterone, including DHEA and epitestosterone – all in a natural way with no changes in the ratio of metabolites or the process, including not increasing any metabolite ratio or level above the normal range.



What it does is ramp up testosterone production up to optimum levels for the individual and not to pharmacological levels. All of what TestoBoost does and doesn’t do is the reason why it 100% won’t and can’t cause a positive drug test.



[i] Nappi RE, Cucinella L. Advances in pharmacotherapy for treating female sexual dysfunction. Expert Opin Pharmacother. 2015 Apr;16(6):875-87.

[ii] Kingsberg SA, Woodard T. Female sexual dysfunction: focus on low desire. Obstet Gynecol. 2015 Feb;125(2):477-86.

[iii] Goldstat R, Briganti E, Tran J, Wolfe R, Davis SR. Transdermal testosterone therapy improves wellbeing, mood, and sexual function in premenopausal women. Menopause. 2003;10:390–8.

[iv] Beattie MC, Adekola L, Papadopoulos V, Chen H, Zirkin BR. Leydig cell aging and hypogonadism. Exp Gerontol. 2015 Feb 18. pii: S0531-5565(15)00076-5.

[v] Tsujimura A. The Relationship between Testosterone Deficiency and Men's Health. World J Mens Health. 2013 Aug;31(2):126-35.

[vi] Chantada Abal V, Vázquez-Martul Pazos D, Portela Pereira P, Aller Rodriguez M, Barreiro Mallo A, Sánchez Vázquez A. [Testosterone deficit syndrome in the old male]. Arch Esp Urol. 2013 Sep;66(7):684-8.

[vii] Travison TG, Morley JE, Araujo AB, O’Donnell AB, McKinlay JB. The relationship between libido and testosterone levels in aging men. J Clin Endocrinol Metab. 2006;91:2509–13.

[viii] Araujo AB, Esche GR, Kupelian V, O’Donnell AB, Travison TG, Williams RE, et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab. 2007;92:4241–5.

[ix] Matsumoto AM. Andropause: Clinical implications of the decline in serum testosterone level with aging in men. J Gerontol A Biol Sci Med Sci. 2002;57:M76–99.

[x] Seidman SN, Weiser M. Testosterone and mood in aging men. Psychiatr Clin North Am. 2013 Mar;36(1):177-82.

[xi] Basaria S. Reproductive aging in men. Endocrinol Metab Clin North Am. 2013 Jun;42(2):255-70.

[xii] Basaria S. Male hypogonadism. Lancet. 2014 Apr 5;383(9924):1250-63.

[xiii] Schreiber G1, Ziemer M.The aging male--diagnosis and therapy of late-onset hypogonadism. J Dtsch Dermatol Ges. 2008 Apr;6(4):273-9.

[xiv] McHenry Martin C. Testosterone deficiency in older men: a problem worth treating. Consult Pharm. 2012 Mar;27(3):152-63.

[xv] Diver MJ, Imtiaz KE, Ahmad AM, Vora JP, Fraser WD. Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men. Clin Endocrinol (Oxf) 2003;58:710–7.

[xvi] Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. 2001. J Clin Endocrinol Metab 86:724–731.

[xvii] Travison TG, Araujo AB, O'Donnell AB, Kupelian V, McKinlay JB. A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metab. 2007 Jan;92(1):196-202.

[xviii] Bhasin S (2007) Secular decline in male reproductive function: Is manliness threatened? J Clin Endocrin & Metab 92: 44–45

[xix] Perheentupa A, Mäkinen - aff-1 J, Laatikainen T, Skakkebaek N, Andersson A, et al (2013) A cohort effect on serum testosterone levels in Finnish men. Eur J Endocrinol 168: 227–233

[xx] Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab. 2002; 87:589–598

[xxi] Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006 Jul;60(7):762-9.

[xxii] Mazur A, Westerman R, Mueller U. Is rising obesity causing a secular (age-independent) decline in testosterone among American men? PLoS One. 2013 Oct 16;8(10):e76178. doi: 10.1371/journal.pone.0076178. eCollection 2013.

[xxiii] Travison TG, Araujo AB, Kupelian V, O’Donnell AB, McKinlay JB. Relative contribution of aging, health, and life-style factors to serum testosterone decline in men. J Clin Endocrinol Metab. 2007;92:549–55.

[xxiv] Klinefelter GR, Laskey JW, Amann RP. Statin drugs markedly inhibit testosterone production by rat Leydig cells in vitro: implications for men. Reprod Toxicol. 2014 Jun;45:52-8.

[xxv] Medras M, Kubicka E, Józkow P, Slowinska-Lisowska M, Trzmiel-Bira A, Filus A. Treatment with statins and testosterone levels in men.Endokrynol Pol. 2014;65(6):464-8.

[xxvi] Fronczak CM, Kim ED, Barqawi AB. The insults of illicit drug use on male fertility. J Androl. 2012 Jul-Aug;33(4):515-28. doi: 10.2164/jandrol.110.011874.

[xxvii] Smith HS, Elliott JA. Opioid-induced androgen deficiency (OPIAD). Pain Physician. 2012 Jul;15(3 Suppl):ES145-56.

[xxviii] Singh P. Andropause: Current concepts. Indian J Endocrinol Metab. 2013 Dec;17(Suppl 3):S621-9.

[xxix] Cook PS, Notelovitz M, Kalra PS, Kalra SP. Effect of diazepam on serum testosterone and the ventral prostate gland in male rats. Arch Androl. 1979;3(1):31-5.

[xxx] Watanabe K, Motoya E, Matsuzawa N, Funahashi T, Kimura T, Matsunaga T, Arizono K, Yamamoto I. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology. 2005 Jan 31;206(3):471-8.

[xxxi] Mandal TK, Das NS. Testicular toxicity in cannabis extract treated mice: association with oxidative stress and role of antioxidant enzyme systems. Toxicol Ind Health. 2010 Feb;26(1):11-23.

[xxxii] Hallinan R, Byrne A, Agho K, McMahon CG, Tynan P, Attia J. Hypogonadism in men receiving methadone and buprenorphine maintenance treatment. Int J Androl. 2009 Apr;32(2):131-9.

[xxxiii] Derby CA, Zilber S, Brambilla D, Morales KH, McKinlay JB. Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf). 2006; 65:125–131.

[xxxiv] Mohr BA, Bhasin S, Link CL, O'Donnell AB, McKinlay JB. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. Eur J Endocrinol. 2006 Sep;155(3):443-52.

[xxxv] Svartberg J, von Mühlen D, Sundsfjord J, Jorde R. Waist circumference and testosterone levels in community dwelling men. The Tromsø study. Eur J Epidemiol. 2004;19(7):657-63.

[xxxvi] Niskanen L, Laaksonen DE, Punnonen K, Mustajoki P, Kaukua J, Rissanen A. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. 2004 May;6(3):208-15.

[xxxvii] Ozata M, Oktenli C, Bingol N, Ozdemir IC. The effects of metformin and diet on plasma testosterone and leptin levels in obese men. Obes Res. 2001 Nov;9(11):662-7.

[xxxviii] Gettler LT, McKenna JJ, McDade TW, Agustin SS, Kuzawa CW. Does cosleeping contribute to lower testosterone levels in fathers? Evidence from the Philippines. PLoS One. 2012;7(9):e41559.

[xxxix] Storey AE, Ziegler TE. Primate paternal care: Interactions between biology and social experience. Horm Behav. 2015 Aug 4. pii: S0018-506X(15)30035-0. doi: 10.1016/j.yhbeh.2015.07.024. [Epub ahead of print]

[xl] Mascaro JS, Hackett PD, Rilling JK. Testicular volume is inversely correlated with nurturing-related brain activity in human fathers. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15746-51.

[xli] Gettler LT, McDade TW, Agustin SS, Feranil AB, Kuzawa CW. Do testosterone declines during the transition to marriage and fatherhood relate to men's sexual behavior? Evidence from the Philippines. Horm Behav. 2013 Nov;64(5):755-63.

[xlii] Wielogórska E, Elliott CT, Danaher M, Connolly L. Endocrine disruptor activity of multiple environmental food chain contaminants. Toxicol In Vitro. 2015 Feb;29(1):211-20.

[xliii] Orton F, Ermler S, Kugathas S, Rosivatz E, Scholze M, Kortenkamp A. Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products. Toxicol Appl Pharmacol. 2014 Aug 1;278(3):201-8.

[xliv] Kortenkamp A. Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals. Environ Health Perspect. 2007 Dec;115 Suppl 1:98-105.

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